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Shortly thereafter, fellow German chemist Leopold Ruzicka developed the means to synthesize such hormones and from their work, in 1935 the first batches of synthetic testosterone were made availableto the military. The hormone was not just the same size as natural testosterone, being several times smaller, but it had much less of an anti-androgenic effect and was therefore much safer. More importantly, this synthetic version did not have any adverse side effects or health problems which were seen with the natural-sized form of testosterone. The synthetic testosterone hormone was a success. A total of 2 million tons of this drug, known as synthetic testosterone, were sold in the United States by the end of World War II. As well, the United States military had to use this substance not only to boost and strengthen its troops, but also in the treatment of battlefield injuries. As military surgeons and chemists were busy at work developing synthetic testosterone, however, many doctors began to question exactly where these substances came from, and wondered if they were, in fact, safe. Indeed, the most notorious case of over-prescription of these new hormones may be the case of a pharmaceutical chemist named Paul W. von Hippel, Jr. Paul von Hippel in his youth. After serving in World War II, Von Hippel became an executive for the pharmaceutical giant Hoffmann-La Roche of New York. He was responsible for creating and testing a synthetic form of testosterone that eventually became known as dextroestradiol. It was initially marketed under the brand name Tylenol. Von Hippel later switched to the company's synthetic product, but only because of a series of health scares. In 1943, while he was at work on a new, safer, hormone, a bomb went off during an internal war laboratory in which he was experimenting. The explosion blew out a piece of the glass wall, spilling a massive amount of dextroestradiol over the surrounding area. Von Hippel's own eyes and retina were badly burned from the chemical, and he was eventually confined to a hospital bed. After being released from hospital, Von Hippel set about trying to find an alternative to the new synthetic hormone. One of Von Hippel's assistants gave him this drug – a concoction made up of natural testosterone and several other chemicals. What he found was very different than what he had expected. Although he had hoped the pills would cause his symptoms to reduce after a short period, when he opened them after taking a week or so he saw that they did the opposite – in an unusual way. The pills made him more aggressive, but when he tried to pass them off as being normal, such Similar articles:
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